CASC3 (NP_031385, 604 a.a. ~ 703 a.a) partial recombinant protein with GST tag. The sequence is VSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGG VTYYNPAQQQVQPKPSPPRRTPQPVTIKPPPPEVVSRGSS
Conjugate
Unconjugated
Target
Alternative Names
CASC3; cancer susceptibility candidate 3; BTZ; MLN51; protein CASC3; MLN 51; barentsz; protein barentsz; metastatic lymph node 51; metastatic lymph node gene 51 protein; cancer susceptibility candidate gene 3 protein;
The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles.
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