CARM1 (NP_954592, 284 a.a. ~ 381 a.a) partial recombinant protein with GST tag. The sequence is NMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTF DIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHS
This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9.
Pathway
Activation of gene expression by SREBF (SREBP); BMAL1:CLOCK,NPAS2 activates circadian gene expression; Coregulation of Androgen receptor activity; Direct p53 effectors
Citations
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