CARD18 (caspase recruitment domain family, member 18) is a protein-coding gene. Diseases associated with CARD18 include chronic lymphocytic leukemia, and leukemia, and among its related super-pathways are Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is CARD17. Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.
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