The product of this gene belongs to the Serine/Threonineprotein kinase family, and to the Ca(2+)/calmodulin-dependentprotein kinase subfamily. This protein plays a role in thecalcium/calmodulin-dependent (CaM) kinase cascade byphosphorylating the downstream kinases CaMK1 and CaMK4. Seventranscript variants encoding six distinct isoforms have beenidentified for this gene. Additional splice variants have beendescribed but their full-length nature has not been determined. Theidentified isoforms exhibit a distinct ability to undergoautophosphorylation and to phosphorylate the downstream kinases.
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References
Structural Characterization of Complexes between 14-3-3 Protein and Protein Kinases CaMKK2 and ASK1