SNP Discovery in Genes Affecting Leg Health Traits in Pigs
ANIMAL GENOMICS FOR ANIMAL HEALTH
Authors: Onteru, S. K.; Fan, B.; Mote, B.; Serenius, T.; Nikkilae, M.; Stalder, K. J.; Rothschild, M. F.
Abstract
Sow reproductive life is influenced by lameness issues. It has been reported that up to 44 percent of sows have locomotive problems. To date, few genome scans or association studies have been conducted to look at genes controlling lameness and other gait traits. In addition to health problems associated with leg and bone disorders, the pig has been suggested to be a good model for human bone disorders. Hence, the present study examined 134 porcine genes affecting skeletal development, mineral metabolism and other candidate genes for single nucleotide polymorphism (SNP) discovery. A total of over 370 SNPs have been identified to date and are being mapped. These SNPs are also being investigated for their associations with gait and locomotion problems in approximately 2,000 commercial pigs scored for various leg and locomotion traits. The association analysis of 22 genes revealed that the genes CALCR, HDBR CALCA, MTHFR, OXTR, 1HH, ANKH, LRCH1 and OPN were significantly associated with leg and body conformation traits which affect the health and productivity of pigs.
The Calcitonin Receptor Gene Is a Candidate for Regulation of Susceptibility to Herpes simplex Type 1 Neuronal Infection Leading to Encephalitis in Rat
PLOS PATHOGENS
Authors: Abdelmagid, Nada; Bereczky-Veress, Biborka; Guerreiro-Cacais, Andre Ortlieb; Bergman, Petra; Luhr, Katarina M.; Bergstrom, Tomas; Skoldenberg, Birgit; Piehl, Fredrik; Olsson, Tomas; Diez, Margarita
Abstract
Herpes simplex encephalitis (HSE) is a fatal infection of the central nervous system (CNS) predominantly caused by Herpes simplex virus type 1. Factors regulating the susceptibility to HSE are still largely unknown. To identify host gene(s) regulating HSE susceptibility we performed a genome-wide linkage scan in an intercross between the susceptible DA and the resistant PVG rat. We found one major quantitative trait locus (QTL), Hse1, on rat chromosome 4 (confidence interval 24.3-31 Mb; LOD score 29.5) governing disease susceptibility. Fine mapping of Hse1 using recombinants, haplotype mapping and sequencing, as well as expression analysis of all genes in the interval identified the calcitonin receptor gene (Calcr) as the main candidate, which also is supported by functional studies. Thus, using unbiased genetic approach variability in Calcr was identified as potentially critical for infection and viral spread to the CNS and subsequent HSE development.
COA
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