Anti-CACNA1F monoclonal antibody, clone 4C3

Antibody Isotype

IgG3

Clone

4C3

Species Reactivity

Human

Immunogen

CACNA1F (NP_005174, 1878 a.a. ~ 1977 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Conjugate

Alternative Names

CACNA1F; calcium channel, voltage-dependent, L type, alpha 1F subunit; AIED, Aland island eye disease (Forsius Eriksson ocular albinism, ocular albinism type 2) , CSNB2; voltage-dependent L-type calcium channel subunit alpha-1F; Cav1.4; COD4; CORDX3; CSNB

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the alpha-1 subunit family; a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants of the gene described here have been observed but have not been thoroughly characterized. Mutations in this gene have been shown to cause incomplete X-linked congential stationary night blindness type 2 (CSNB2).

Pathway

Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Axon guidance, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem;