Anti-CACNA1C (aa 2039-2138) polyclonal antibody

Species Reactivity

Human; Rat

Immunogen

CACNA1C (NP_000710, 2039 a.a. ~ 2138 a.a) partial recombinant protein with GST tag. The sequence is AVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGALLPFV NCRDAGQDRAGGEEDAGCVRARGRPSEEELQDSRVYVSSL

Conjugate

Alternative Names

CACNA1C; calcium channel, voltage-dependent, L type, alpha 1C subunit; TS; LQT8; CACH2; CACN2; CaV1.2; CCHL1A1; CACNL1A1; voltage-dependent L-type calcium channel subunit alpha-1C; DHPR, alpha-1 subunit; voltage-dependent L-type Ca2+ channel alpha 1 subun

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits.

Pathway

Adrenaline,noradrenaline inhibits insulin secretion; Alzheimers disease; Amphetamine addiction; Arrhythmogenic right ventricular cardiomyopathy (ARVC)