Anti-CACNA1A monoclonal antibody, clone FQS5569(O)

Antibody Isotype

IgG

Clone

FQS5569(O)

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human CACNA1A aa 2050-2150 (Cysteine residue). The exact sequence is proprietary.Database link: O00555

Conjugate

Application Notes

WB: 1/1000 - 1/5000; Flow Cyt: 1/10 - 1/100;

Alternative Names

CACNA1A; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; CACNL1A4, MHP, MHP1, SCA6; voltage-dependent P/Q-type calcium channel subunit alpha-1A; APCA; Cav2.1; EA2; FHM; HPCA; brain calcium channel 1; brain calcium channel I; calcium channe

Entrez Gene ID

UniProt ID

Antigen Description

Cav2.1 is a voltage-sensitive calcium channels (VSCC) which belongs to the calcium channel alpha-1 subunit family. Cav2.1 mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Cav2.1 (isoform alpha-1A) gives rise to P and/or Q-type calcium currents. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.

Pathway

Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Cholinergic synapse, organism-specific biosystem; Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem;