Anti-CA5B monoclonal antibody (DCABH-10799) Made to order

Rabbit anti-Human CA5B monoclonal antibody for WB, ELISA

View other CA5B antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human CA5B is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
CA5B; carbonic anhydrase VB, mitochondrial; carbonic anhydrase 5B, mitochondrial; carbonic dehydratase; carbonate dehydratase VB; CA-VB
Entrez Gene ID
UniProt ID

Product Background


Gene summary
CA5B (Carbonic Anhydrase 5B) is a Protein Coding gene. Diseases associated with CA5B include heart conduction disease and heart septal defect. Among its related pathways are Metabolism and Nitrogen metabolism. GO annotations related to this gene include carbonate dehydratase activity. An important paralog of this gene is CA14. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles.
Antigen Description
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. Reversible hydration of carbon dioxide. Carbonic anhydrase 5B, mitochondrial is an enzyme that in humans is encoded by the CA5B gene. 0The function about CA5B antigen include carbonate dehydratase activity; lyase activity; metal ion binding; zinc ion binding.

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Maresca, A; Supuran, CT; et al. (R)-/(S)-10-Camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21:1334-1337(2011).
Supuran, CT; et al. Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity. EXPERT OPINION ON EMERGING DRUGS 17:11-15(2012).

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