Anti-CA3 monoclonal antibody, clone FQS24537

Ca3Ti2O7 with Ruddlesden-Popper structure exhibits the largest polarization among the known hybrid improper ferroelectrics. However, the high Curie temperature impedes the thorough study of phase transition through dielectric characterization. According to the previous theoretical design rule, the Curie temperature can be suppressed by increasing the tolerance factor. So, in the present work, high-quality Ca3-xLaxTi2-xAlxO7 (x = 0.0, 0.1, 0.2, 0.3) ceramics with increased tolerance factors were successfully prepared. The amplitude of oxygen octahedral tilt mode indeed decreases with increasing tolerance factors, leading to a degeneration of ferroelectric polarization. However, the unexpected rigid rotation mode causes the composition-invariable coercive fields. The Curie temperatures decrease linearly with increasing x and tolerance factors. The variable-temperature dielectric constant confirms first-order improper ferroelectric transitions in Ca3Ti2O7-based ceramics. The results of variable temperature X-ray diffraction reveal the coexistence of two-phases below Curie temperature. The present work confidently confirms the first-order improper ferroelectric transition in Ca3Ti2O7-based ceramics by combining results of variable-temperature dielectric response and in-situ X-ray powder diffraction. (C) 2019 The Chinese Ceramic Society. Production and hosting by Elsevier B.V.

An alteration of oxytocin signaling during postnatal maturation of the brain could be associated with etiology of neurodevelopmental disorders among them autism. The aim of the present study was to examine the role of oxytocin in the regulation of expression of selected cell-adhesion molecules and scaffolding proteins in the hippocampus in early rat development. Oxytocin treatment (1 mg/ml, i.p., 50 mu l/pup) at postnatal days P2-P3 resulted in the reduction of Neuroligin 3 gene expression, and was accompanied by lower SHANK1 and SHANK3 mRNA levels in the hippocampus at P5 day. Immunostaining revealed a clear trend for the lower density of Neuroligin 3 positive cells in the hippocampus and this trend has been significant in the CA3 hippocampal area. The significantly lower Neurexin 2 beta mRNA levels were observed in response to oxytocin treatment, with no effect seen in the Neurexin 2 alpha gene expression. No change has been observed in the gene expression of Neuroligin 1 and Neuroligin 2. Oxytocin induced an increase in the mRNA levels of Neuron-Specific Enolase (NSE) and a decrease in the mRNA levels of glial fibrillary acid protein (GFAP) - marker of astrocytes. Incubation of primary neuronal cells with oxytocin (1 mu M, 48 h) stimulated a proliferation of NSE-positive cells. These results suggest that synaptic proteins could be under control of oxytocin in early stages of brain development. The changes of cell-adhesion molecule and scaffolding protein levels might be linked to the modulation of number of neuronal cells.