Anti-C8A monoclonal antibody, clone 167C-484

Antibody Isotype

IgG1

Clone

167C-484

Species Reactivity

Human

Immunogen

Purified human C8

Conjugate

Alternative Names

C8A; complement component 8, alpha polypeptide; complement component C8 alpha chain; complement component 8 subunit alpha;

Entrez Gene ID

UniProt ID

Antigen Description

C8 is synthesised in the liver, monocytes and fibroblasts and is a plasma protein consisting of three non identical polypeptide chains. The alpha-chain (64kDa) and gamma chain (22kDa) are disulphide linked, these associate non-covalently with the beta-chain (64kDa), to form the native C8 molecule with a molecular weight of 151kDa. Normal plasma concentration is 80mg/L. C8 is one of the terminal proteins of the complement pathways. C8 binds to the membrane bound C5b-7, C5b-8 combines with C9 to form the membrane attack complex (MAC). The MAC forms a hydrophilic, protein walled, transmembrane channel, formation of which leads to cell lysis and destruction.

Pathway

Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Complement Activation, Classical Pathway, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; Immune System, organism-specific biosystem.