C7ORF30 (chromosome 7 open reading frame 30) is a gene on chromosome 7 in humans that encodes the protein LOC_115416. This protein localizes to mitochondria and is probably involved in mitochondrial translation or the biogenesis of the large subunit of the mitochondrial ribosome. MALSU1 (mitochondrial assembly of ribosomal large subunit 1) is a protein-coding gene. Diseases associated with MALSU1 include pneumonia, and tuberculosis. May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome.
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