Rabbit Anti-Human C7orf49 (a.a. 1-129) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant human C7orf49 protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 1-129 aa of BC000168

Conjugate

Application Notes

IHC: 1:50-1:500

General Notes

This product (Catalog No. DPABH-12387) is a rabbit-derived polyclonal antibody raised against human C7orf49, targeting the amino acid region 1–129 of the protein. It has been affinity purified by Protein A. CYREN, also known as cell cycle regulator of non-homologous end joining, is a microprotein encoded by the human CYREN gene (previously C7orf49) located on chromosome 7q33 that plays a critical role in regulating DNA double-strand break (DSB) repair pathway choice in mammalian cells. As an intrinsically disordered 157-amino-acid protein expressed from a small open reading frame (smORF), CYREN specifically inhibits classical non-homologous end joining (cNHEJ) during the S and G2 phases of the cell cycle, thereby promoting error-free repair via homologous recombination (HR) when sister chromatids are available as templates. This cell cycle-dependent regulation prevents error-prone cNHEJ from dominating in phases where HR is preferable, reducing genomic instability and chromosomal aberrations such as fusions and bridges that arise from inappropriate end-joining at overhang-bearing breaks.
DPABH-12387 is suitable for use in IHC (1:50–1:500) application.
DPABH-12387 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

Cell cycle regulator of NHEJ; Cell cycle regulator of non-homologous end joining; CYREN; MRI

Entrez Gene ID

UniProt ID