Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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HOUGH, MR; ROSTEN, PM; et al. MAPPING OF CD24 AND HOMOLOGOUS SEQUENCES TO MULTIPLE CHROMOSOMAL LOCI. GENOMICS 22:154-161(1994).
Zhu, XL; Naz, RK; et al. Cloning and sequencing of cDNA encoding for a human sperm antigen involved in fertilization. MOLECULAR REPRODUCTION AND DEVELOPMENT 51:176-183(1998).
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