Anti-C13ORF15 monoclonal antibody (DCABH-10780) Made to order

Rabbit anti-Human C13ORF15 monoclonal antibody for WB, ELISA

View other C13ORF15 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human C13orf15 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
C13ORF15; chromosome 13 open reading frame 15; C13orf15, chromosome 13 open reading frame 15; bA157L14.2; response gene to complement 32; RGC 32
Entrez Gene ID

Product Background


Gene summary
RGCC (Regulator Of Cell Cycle) is a Protein Coding gene. Diseases associated with RGCC include renal fibrosis. Among its related pathways are Gene Expression and Direct p53 effectors. GO annotations related to this gene include protein kinase binding and R-SMAD binding. This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression.
Antigen Description
This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. Regulator of cell cycle RGCC (RGCC) also known as response gene to complement 32 protein (RGC-32) is a protein that in humans is encoded by the RGCC gene.

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References


Ryerse, J; BlachlyDyson, E; et al. Cloning and molecular characterization of a voltage-dependent anion-selective channel (VDAC) from Drosophila melanogaster. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1327:204-212(1997).

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