Beta-lactamases; β-lactamase domain; Type IV beta-lactamase; Enterobacter cloacae; EC 3.5.2.6; Bacteria; Proteobacteria; Gamma Proteobacteria; Enterobacteriales; Enterobacteriaceae; Enterobacter; E. c. subsp. cloacae; E. c. subsp. dissolvens; Bacillus clo
Product Background
Antigen Description
The beta-lactam antibiotics (penicillins and cephalosporins) are the most frequently used antimicrobial agents. All of the beta-lactams are structurally related through the presence of a core beta-lactam ring. Bacterial resistance to beta-lactams continues to increase, primarily due to the production of betalactamases. Beta-lactamases catalyze the hydrolysis of the beta-lactam bond which destroys antibacterial activity. Bacteria that produce TEM- or SHVtype beta-lactamases have point mutations in structural genes that have extended the substrate specificity of these beta-lactamases. As a result, many of the beta-lactamase-producing Gram-negative pathogens have become multi-drug resistant.
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