Anti-BTRC polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide conjugated to KLH derived from within residues 550 to the C-terminus of Human Beta TRCP.

Conjugate

Application Notes

IHC-P: 1 μg/ml; WB: 1 μg/ml; ICC/IF: 5 μg/ml;

Alternative Names

BTRC; beta-transducin repeat containing E3 ubiquitin protein ligase; FWD1; FBW1A; FBXW1; bTrCP; FBXW1A; bTrCP1; betaTrCP; BETA-TRCP; F-box/WD repeat-containing protein 1A; beta-TrCP1; E3RSIkappaB; F-box and WD-repeat protein 1B; epididymis tissue protein

Entrez Gene ID

UniProt ID

Antigen Description

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at Lys-21 and Lys-22. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.

Pathway

APC/C-mediated degradation of cell cycle proteins; Adaptive Immune System; Antigen processing: Ubiquitination & Proteasome degradation; Canonical NF-kappaB pathway