Anti-BTK monoclonal antibody (DCABH-733)

Mouse anti-Human BTK monoclonal antibody for WB, IHC-P, ICC/IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG2a
Clone
21F21
Species Reactivity
Human
Immunogen
Recombinant full length Human BTK produced in HEK293T cells (NP_000052).
Conjugate
Unconjugated

Applications


Application Notes
WB: 1/2000; IHC-P: 1/50; ICC/IF: 1/100;
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
BTK; Bruton agammaglobulinemia tyrosine kinase; AGMX1, IMD1; tyrosine-protein kinase BTK; ATK; PSCTK1
Entrez Gene ID
UniProt ID

Product Background


Pathway
Adaptive Immune System, organism-specific biosystem; Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; B cell receptor signaling pathway, organism-specific biosystem; B cell receptor signaling pathway, conserved biosystem; BCR signaling pathway, organism-specific biosystem; Class I PI3K signaling events, organism-specific biosystem;

Citations


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References


Wu, HJ; Bondada, S; et al. CD72, a Coreceptor with Both Positive and Negative Effects on B Lymphocyte Development and Function. JOURNAL OF CLINICAL IMMUNOLOGY 29:12-21(2009).
Herrmann, H; Blatt, K; et al. Glucocorticosteroids Rescue Basophils from Dasatinib-Augmented Immunoglobulin E-Mediated Histamine Release. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 159:15-22(2012).

Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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