Rabbit Anti-Human BMP10 (a.a. 154-333) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant human BMP10 protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 154-333 aa of BC105063

Conjugate

Application Notes

WB: 1:500-1:1000

General Notes

This product (Catalog No. DPABH-08515) is a rabbit-derived polyclonal antibody raised against human BMP10, targeting the amino acid region 154–333 of the protein. It has been affinity purified by Protein A. Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.
DPABH-08515 is suitable for use in Western blot (WB) (1:500–1:1,000) application.
DPABH-08515 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

BMP 10; BMP-10; Bone morphogenetic protein 10

Entrez Gene ID

UniProt ID