Mouse anti-Human BHLHE41 polyclonal antibody

Species Reactivity

Human

Immunogen

BHLHB3 (NP_110389, 203 a.a. ~ 282 a.a) partial recombinant protein with GST tag. The sequence is CLERAGQKLEPLAYCVPVIQRTQPSAELAAENDTDTDSGYGGEAEARPDREKGKGAGASR VTIKQEPPGEDSPAPKRMKL

Conjugate

Alternative Names

BHLHE41; basic helix-loop-helix family, member e41; DEC2; hDEC2; BHLHB3; SHARP1; class E basic helix-loop-helix protein 41; enhancer-of-split and hairy-related protein 1; differentially expressed in chondrocytes protein 2; basic helix-loop-helix domain co

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a basic helix-loop-helix protein expressed in various tissues. The encoded protein can interact with ARNTL or compete for E-box binding sites in the promoter of PER1 and repress CLOCK/ARNTLs transactivation of PER1. This gene is believed to be involved in the control of circadian rhythm and cell differentiation. Defects in this gene are associated with the short sleep phenotype.

Pathway

BMAL1:CLOCK,NPAS2 activates circadian gene expression; Circadian rhythm; HIF-1-alpha transcription factor network;