Anti-BHLHA15 monoclonal antibody, clone 2I2/F6/F6

Antibody Isotype

IgG

Clone

2I2/F6/F6

Species Reactivity

Mouse

Immunogen

Synthetic peptide: MKTKNRPPRRRTPMQDTEAT, corresponding to N terminal amino acids 1-20 of Mouse BHLHA15 (Q9QYC3)

Conjugate

Application Notes

WB: 1/250;

Alternative Names

BHLHA15; basic helix-loop-helix family, member a15; class A basic helix-loop-helix protein 15; MIST-1; class B basic helix-loop-helix protein 8; muscle, intestine and stomach expression 1; basic helix-loop-helix domain containing, class B, 8; Mist1; Bhlhb

Entrez Gene ID

UniProt ID

Antigen Description

Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5-CANNTG-3.

Pathway

Maturity onset diabetes of the young, organism-specific biosystem; Maturity onset diabetes of the young, conserved biosystem;