Anti-BCL2L12 monoclonal antibody (CAB-2773MH)
Mouse anti-BCL2L12 monoclonal antibody for ELISA, WB
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BCL2L12 (AAH07724, 174 a.a. - 273 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.
BCL2L12; BCL2-like 12 (proline rich); bcl-2-like protein 12; bcl2-L-12; Bcl-2 related proline-rich protein; bcl-2-related proline-rich protein
BCL2L12 (BCL2 Like 12) is a Protein Coding gene. GO annotations related to this gene include p53 binding. This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Protein Symbol:Q9HB09-B2L12_HUMANRecommended name:Bcl-2-like protein 12Protein Accession:Q9HB09Secondary Accessions:Q3SY11Q3SY13Q96I96Q9HB08Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.
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Jensen, SA; Day, ES; et al. Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma. SCIENCE TRANSLATIONAL MEDICINE 5:-(2013).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.