Anti-B3GNT5 monoclonal antibody (DCABH-10696) Made to order

Rabbit anti-Human B3GNT5 monoclonal antibody for WB, ELISA

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human B3GNT5 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
B3GNT5; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5; B3GN T5; beta3Gn T5; BGnT-5; lc3 synthase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
B3GNT5 (UDP-GlcNAc:BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 5) is a Protein Coding gene. Among its related pathways are Metabolism and O-linked glycosylation. GO annotations related to this gene include oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen and beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity. An important paralog of this gene is B3GALT2. This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids.
Antigen Description
This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids. Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Probably plays a central role in regulating neolacto-series glycolipid synthesis during embryonic development. The function about B3GNT5 antigen include beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity; galactosyltransferase activity; lipopolysaccharide N-acetylglucosaminyltransferase activity; transferase activity, transferring glycosyl group.
Pathway
Glycosphingolipid biosynthesis - lacto and neolacto series, organism-specific biosystem; Glycosphingolipid biosynthesis - lacto and neolacto series, conserved biosystem; Glycosphingolipid biosynthesis, lacto-series, LacCer => Lc4Cer, organism-specific biosystem; Lc4Cer, conserved biosystem; Glycosphingolipid biosynthesis, neolacto-series, LacCer =>.

Citations


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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Kuan, CT; Chang, JL; et al. Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase-a key enzyme in lacto-neolacto ganglioside synthesis. BMC DEVELOPMENTAL BIOLOGY 10:-(2010).
Biellmann, F; Hulsmeier, AJ; et al. The Lc3-synthase gene B3gnt5 is essential to pre-implantation development of the murine embryo. BMC DEVELOPMENTAL BIOLOGY 8:-(2008).

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