Anti-B3GALNT1 monoclonal antibody (DCABH-10692) Made to order

Rabbit anti-Human B3GALNT1 monoclonal antibody for WB, ELISA

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human B3GALNT1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
B3GALNT1; beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group); B3GALT3, UDP Gal:betaGlcNAc beta 1,3 galactosyltransferase, polypeptide 3 (Globoside blood group) , UDP GalNAc:betaGlcNAc beta 1,3 galactosaminyltransferase, polypeptide 1 (Gl
Entrez Gene ID
UniProt ID

Product Background


Gene summary
B3GALNT1 (Beta-1,3-N-Acetylgalactosaminyltransferase 1 (Globoside Blood Group)) is a Protein Coding gene. Among its related pathways are Glycosphingolipid biosynthesis - globo series and Metabolism. GO annotations related to this gene include transferase activity, transferring glycosyl groups and UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. An important paralog of this gene is B3GNT5. This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). The encoded protein of this gene does not use N-acetylglucosamine as an acceptor sugar at all. Multiple transcript variants that are alternatively spliced in the 5' UTR have been described; they all encode the same protein.
Antigen Description
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). The encoded protein of this gene does not use N-acetylglucosamine as an acceptor sugar at all. Multiple transcript variants that are alternatively spliced in the 5 UTR have been described; they all encode the same protein. Transfers N-acetylgalactosamine onto globotriaosylceramide. UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the B3GALNT1 gene. 0The function about B3GALNT1 antigen include UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity; galactosyltransferase activity; transferase activity, transferring glycosyl groups.
Pathway
Glycosphingolipid biosynthesis - globo series, organism-specific biosystem; Glycosphingolipid biosynthesis - globo series, conserved biosystem; Glycosphingolipid biosynthesis, globo-series, LacCer => Gb4Cer, organism-specific biosystem; Gb4Cer, conserved biosystem; Metabolic pathways, organism-specific biosystem.

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References


TAKEYA, A; HOSOMI, O; et al. BIOSYNTHESIS OF THE BLOOD GROUP-P ANTIGEN-LIKE GALNAC-BETA-1-]3GAL-BETA-1-] 4GLCNAC/GLC STRUCTURE - A NOVEL NORMAL-ACETYLGALACTOSAMINYLTRANSFERASE IN HUMAN BLOOD-PLASMA. JOURNAL OF BIOCHEMISTRY 112:389-395(1992).

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