This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Zhang, LS; Nebane, NM; et al. A High-Throughput Screen for Chemical Inhibitors of Exocytic Transport in Yeast. CHEMBIOCHEM 11:1291-1301(2010).
Thompson, A; Shi, XL; et al. Identification of proteins from the yeast haploid deletion library involved in Fre1 activity: Novel involvement of Pho85 and Avl9 in Mac1 activation. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 232:796-796(2006).
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