Anti-ATPase p97 monoclonal antibody (DMAB3012)

Mouse anti-ATPase p97 monoclonal antibody for WB Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
A60.14.4
Species Reactivity
N/A
Immunogen
15S Mg2+ ATPase complex purified from Xenopus laevis ovary
Conjugate
Unconjugated

Target


Alternative Names
15S Mg(2+) ATPase p97 subunit; 15S Mg(2+)-ATPase p97 subunit; ATPase p97; IBMPFD; MGC131997; MGC148092

Product Background


Antigen Description
Defects in VCP arethe cause of inclusion body myopathy with early-onset Paget disease andfrontotemporal dementia (IBMPFD) [MIM:167320]; also known as musculardystrophy, limb-girdle, with Paget disease of bone or pagetoid amyotrophiclateral sclerosis or pagetoid neuroskeletal syndrome or lower motor neurondegeneration with Paget-like bone disease. IBMPFD features adult-onsetproximal and distal muscle weakness (clinically resembling limb girdlemuscular dystrophy), early-onset Paget disease of bone in most cases andpremature frontotemporal dementia. Suitable for use in Western blot (1:1,000 – 1:2,000). Not for use in immunofluorescence and immunoprecipitation. Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Citations


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References


Jenkins, H; Sakurai, Y; et al. Randomised clinical trial: safety, tolerability, pharmacokinetics and pharmacodynamics of repeated doses of TAK-438 (vonoprazan), a novel potassium-competitive acid blocker, in healthy male subjects. ALIMENTARY PHARMACOLOGY & THERAPEUTICS 41:636-648(2015).
Yao, J; Li, J; et al. Protein Kinase C Inhibitor, GF109203X Attenuates Osteoclastogenesis, Bone Resorption and RANKL-Induced NF-kappa B and NFAT Activity. JOURNAL OF CELLULAR PHYSIOLOGY 230:1235-1242(2015).

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We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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