Goat anti-Human ATP7A polyclonal antibody

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to human ATP7A. The sequence is C-HKNNWNIEDNNIKN

Conjugate

Alternative Names

ATP7A; ATPase, Cu++ transporting, alpha polypeptide; MK; MNK; DSMAX; SMAX3; copper-transporting ATPase 1; copper pump 1; Cu++-transporting P-type ATPase; Menkes disease-associated protein;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed.

Pathway

Cellular responses to stress; Ion channel transport; Mineral absorption; Transmembrane transport of small molecules