General Notes
This product (Catalog No. DPABH-11103) is a rabbit-derived polyclonal antibody raised against human ATP6V1G1, targeting the amino acid region 1–118 of the protein. It has been affinity purified by Protein A. ATP6V1G1 (ATPase H⁺-transporting V1 subunit G1) encodes a component of the V1 domain of the vacuolar-type proton ATPase (V-ATPase) complex, which is responsible for acidifying intracellular compartments such as lysosomes, endosomes, and secretory vesicles. The V1 sector is the cytoplasmic catalytic domain that hydrolyzes ATP to provide energy for proton translocation across membranes mediated by the V0 sector. ATP6V1G1 is involved in maintaining organelle pH homeostasis, protein degradation, receptor recycling, and intracellular trafficking. Proper function of this subunit is essential for neuronal activity, bone resorption, and general cellular metabolic regulation. Dysregulation of ATP6V1G1 or V-ATPase activity has been linked to neurodegenerative diseases, cancer progression, and metabolic disorders.
DPABH-11103 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-11103 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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