Anti-ATP6V0B monoclonal antibody (DCABH-10675) Made to order

Rabbit anti-Human ATP6V0B monoclonal antibody for WB, ELISA

View other ATP6V0B antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ATP6V0B is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ATP6V0B; ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b; ATP6F, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 21kD , ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c; V-type proton ATPase 21 kDa proteolipid subunit; HATPL; VMA16
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ATP6V0B (ATPase H+ Transporting V0 Subunit B) is a Protein Coding gene. Diseases associated with ATP6V0B include lymphocytic choriomeningitis. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include transporter activity and hydrogen ion transmembrane transporter activity. This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants.
Antigen Description
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. V-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene. 0The function about ATP6V0B antigen include hydrogen ion transmembrane transporter activity; transporter activity.
Pathway
Epithelial cell signaling in Helicobacter pylori infection, organism-specific biosystem; Epithelial cell signaling in Helicobacter pylori infection, conserved biosystem; Insulin receptor recycling, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Metabolic pathways, organism-specific biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Goossens, K; Van Soom, A; et al. Identification and expression analysis of genes associated with bovine blastocyst formation. BMC DEVELOPMENTAL BIOLOGY 7:-(2007).
Pemov, A; Sung, HJ; et al. Genetic Modifiers of Neurofibromatosis Type 1-Associated Cafe-au-Lait Macule Count Identified Using Multi-platform Analysis. PLOS GENETICS 10:-(2014).

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