General Notes
This product (Catalog No. DPABH-03357) is a rabbit-derived polyclonal antibody raised against human ATP6AP2, targeting the amino acid region 17–302 of the protein. This antibody exhibits cross-reactivity with Human ATP6AP2 from mouse and rat. It has been affinity purified by Protein A. The (pro)renin receptor (PRR), also known as ATP6AP2, is a single-pass transmembrane protein encoded by the ATP6AP2 gene on the X chromosome. It is ubiquitously expressed across tissues including the kidney, heart, brain, and placenta. While initially identified for its high-affinity binding to renin and its inactive precursor prorenin, PRR's primary established function is as an accessory subunit for vacuolar H⁺-ATPase (V-ATPase) biogenesis, with additional roles in regulation of autophagy and participation in Wnt/β-catenin signaling. The protein was discovered in 2002 through expression cloning from a human kidney cDNA library, revealing its proposed capacity to enhance the catalytic efficiency of prorenin and renin in cleaving angiotensinogen to angiotensin I; however, the physiological relevance of this role in tissue-specific activation of the renin-angiotensin system (RAS) remains debated and uncertain.
DPABH-03357 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-03357 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
Alternative Names
Renin/prorenin receptor; ER-localized type I transmembrane adapter; ATPase H(+)-transporting lysosomal accessory protein 2; CAPER; ATP6M8-9; Embryonic liver differentiation factor 10; ATP6AP2; ATPase H(+)-transporting lysosomal-interacting protein 2; V-ATPase M8.9 subunit; ATP6IP2; Renin receptor; N14F; ELDF10; Vacuolar ATP synthase membrane sector-associated protein M8-9
COA
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