Synthetic peptide within Human ATG4A aa 7-37 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: Q8WYN0
Conjugate
Unconjugated
Applications
Application Notes
WB: 1/100 - 1/500; IHC-P: 1/50 - 1/100.
Target
Alternative Names
ATG4A; ATG4 autophagy related 4 homolog A (S. cerevisiae); APG4 autophagy 4 homolog A (S. cerevisiae); APG4A, AUT like 2, cysteine endopeptidase (S. cerevisiae); AUTL2; cysteine protease ATG4A; hAPG4A; autophagin 2; autophagin-2; APG4 autophagy 4 homolog
Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP.
Pathway
Regulation of autophagy.
Citations
Publication ()
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COA
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