Synthetic peptide corresponding to a region within C terminal amino acids 397-446 (HKDCPVTALQ KKTQGYLESP KESSEPTGSP APVIQHSSAT APSNGLSVRS) of Rat ATF7 (NP_001101585).
Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5-GTGACGT[AG][AG]-3), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.
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