Anti-ATF6B monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human ATF6B is used for rabbit immunization.

Conjugate

Alternative Names

ATF6B; activating transcription factor 6 beta; cAMP responsive element binding protein like 1 , CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta; G13; ATF6-beta; protein G13; Creb-related protein; cAMP responsive element binding protein-like 1

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.

Pathway

Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; Cocaine addiction, organism-specific biosystem; Cocaine addiction, conserved biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; G1 to S cell cycle control, organism-specific biosystem;