General Notes
This product (Catalog No. DPABH-25122) is a rabbit-derived polyclonal antibody raised against human ATF2, targeting the amino acid region 2–107 of the protein. It has been affinity purified by Protein A. CREB2, also known as ATF4, represents a distinct family variant that functions predominantly as a transcriptional repressor, featuring a bZIP domain with specificity for CRE-like elements but lacking strong activation motifs in its N-terminal region. This isoform's repressive activity stems from its ability to form heterodimers with other bZIP proteins, such as ATF3, thereby competing with activator isoforms like CREB1 for binding sites and inhibiting gene expression, particularly under stress conditions.
DPABH-25122 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-25122 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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