Anti-ASIC1 (aa 499-528) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide within Human ACCN2 aa 499-528 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.Database link: P78348

Conjugate

Application Notes

WB: 1/100 - 1/500; Flow Cyt: 1/10 - 1/100; IHC-P: 1/50 - 1/100;

Alternative Names

ASIC1; acid-sensing (proton-gated) ion channel 1; ASIC; ACCN2; BNaC2; acid-sensing ion channel 1; brain sodium channel 2; acid-sensing ion channel 1a protein; amiloride-sensitive cation channel 2, neuronal; Cation channel, amiloride-sensitive, neuronal, 2

Entrez Gene ID

UniProt ID

Antigen Description

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.

Pathway

Inflammatory mediator regulation of TRP channels; Ion channel transport; Transmembrane transport of small molecules.