General Notes
This product (Catalog No. DPABH-21698) is a rabbit-derived polyclonal antibody raised against human ASGR1, targeting the amino acid region 62–291 of the protein. This antibody exhibits cross-reactivity with Human ASGR1 from rat. It has been affinity purified by Protein A. The asialoglycoprotein receptor (ASGPR) is a transmembrane C-type lectin receptor predominantly expressed on hepatocytes, serving as a key mediator for the clearance of desialylated glycoproteins—serum proteins lacking terminal sialic acid residues—from the bloodstream via receptor-mediated endocytosis. First identified in the 1960s, ASGPR plays a crucial role in maintaining glycoprotein homeostasis in mammals by recognizing terminal galactose (Gal) or N-acetylgalactosamine (GalNAc) residues on ligands in a calcium-dependent manner, with a high affinity for multivalent structures. Composed of two major subunits, ASGR1 (the primary functional subunit, approximately 46 kDa) and ASGR2 (approximately 50 kDa), it forms hetero-oligomeric complexes on the cell surface, enabling efficient binding and internalization through clathrin-coated pits followed by rapid lysosomal degradation or receptor recycling.
DPABH-21698 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-21698 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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