Anti-ASCL1 (aa 137-236) polyclonal antibody

Species Reactivity

Human

Immunogen

ASCL1 (NP_004307, 137 a.a. ~ 236 a.a) partial recombinant protein with GST tag. The sequence is GFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPN YSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF

Conjugate

Alternative Names

ASCL1; achaete-scute family bHLH transcription factor 1; ASH1; HASH1; MASH1; bHLHa46; achaete-scute homolog 1; ASH-1; achaete scute protein; achaete-scute complex-like 1; achaete-scute complex homolog 1; class A basic helix-loop-helix protein 46;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5-CANNTG-3). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.

Pathway

Delta-Notch Signaling Pathway; Notch-mediated HES/HEY network;