Anti-AS3MT monoclonal antibody (DCABH-10627) Made to order

Rabbit anti-Human AS3MT monoclonal antibody for WB, ELISA

View other AS3MT antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human AS3MT is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
AS3MT; arsenic (+3 oxidation state) methyltransferase; arsenite methyltransferase; CYT19; methyltransferase cyt19; methylarsonite methyltransferase
Entrez Gene ID
UniProt ID

Product Background


Gene summary
AS3MT (Arsenite Methyltransferase) is a Protein Coding gene. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include methyltransferase activity and protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al. , 2002 [PubMed 11790780]).
Antigen Description
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al. , 2002 [PubMed 11790780]). Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity). Arsenite methyltransferase is an enzyme that in humans is encoded by the AS3MT gene. 0The function about AS3MT antigen include arsenite methyltransferase activity; methylarsonite methyltransferase activity; methyltransferase activity; transferase activity.
Pathway
arsenate detoxification I (glutaredoxin), organism-specific biosystem; arsenate detoxification I (glutaredoxin), conserved biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


John, JPP; Oh, JE; et al. Identification and characterisation of arsenite (+3 Oxidation State) methyltransferase (AS3MT) in mouse neuroblastoma cell line N1E-115. AMINO ACIDS 35:355-358(2008).

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