Anti-ARSG monoclonal antibody (DCABH-10622) Made to order

Rabbit anti-Human ARSG monoclonal antibody for WB, ELISA

View other ARSG antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ARSG is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ARSG; arylsulfatase G; KIAA1001; ASG
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ARSG (Arylsulfatase G) is a Protein Coding gene. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include sulfuric ester hydrolase activity and arylsulfatase activity. An important paralog of this gene is ARSJ. The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene.
Antigen Description
Sulfatases, such as ARSG, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This gene, a novel arylsulfatase, has activity toward pseudosubstrates including p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. Activity is competitively inhibited by phosphate. The unprocessed protein is active as a 63-kDa monomer and demonstrates an acidic pH optimum as typically seen for lysosomal sulfatases. The protein accumulates within lysosomes and is also a glycoprotein that binds specifically to mannose 6-phosphate receptors. Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. The function about ARSG antigen include arylsulfatase activity; NOT arylsulfatase activity; arylsulfatase activity; hydrolase activity; metal ion binding.
Pathway
Lysosome, organism-specific biosystem; Lysosome, conserved biosystem.

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References


Wu, JT; Chiang, KC; et al. Expression of progesterone receptor(s) during capacitation and incidence of acrosome reaction induced by progesterone and zona proteins in boar spermatozoa. ANIMAL REPRODUCTION SCIENCE 93:34-45(2006).
EGESTEN, A; WELLER, PF; et al. ARYLSULFATASE-B IS PRESENT IN CRYSTALLOID-CONTAINING GRANULES OF HUMAN EOSINOPHIL GRANULOCYTES. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 104:207-210(1994).

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