Anti-ARHGEF12 monoclonal antibody (DCABH-10593) Made to order

Rabbit anti-Human ARHGEF12 monoclonal antibody for WB, ELISA

View other ARHGEF12 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ARHGEF12 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ARHGEF12; Rho guanine nucleotide exchange factor (GEF) 12; rho guanine nucleotide exchange factor 12; KIAA0382; LARG; leukemia-associated RhoGEF
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ARHGEF12 (Rho Guanine Nucleotide Exchange Factor 12) is a Protein Coding gene. Diseases associated with ARHGEF12 include leukemia, acute myeloid and shwachman-diamond syndrome. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity and G-protein coupled receptor binding. An important paralog of this gene is ARHGEF18. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene.
Antigen Description
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia. Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with KMT2A/MLL1. Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptor. The function about ARHGEF12 antigen include G-protein coupled receptor binding; GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity.
Pathway
Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Developmental Biology, organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Majumdar, M; Seasholtz, TM; et al. A Rho exchange factor mediates thrombin and G alpha(12)-induced cytoskeletal responses. JOURNAL OF BIOLOGICAL CHEMISTRY 274:26815-26821(1999).

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