Anti-APCS (aa 117-223) polyclonal antibody

Species Reactivity

Human

Immunogen

APCS (NP_001630, 117 a.a. ~ 223 a.a) partial recombinant protein with GST tag. The sequence is WESSSGIAEFWINGTPLVKKGLRQGYFVEAQPKIVLGQEQDSYGGKFDRSQSFVGEIGDL YMWDSVLPPENILSAYQGTPLPANILDWQALNYEIRGYVIIKPLVWV

Conjugate

Alternative Names

APCS; amyloid P component, serum; SAP; PTX2; HEL-S-92n; serum amyloid P-component; pentaxin-related; 9.5S alpha-1-glycoprotein; epididymis secretory sperm binding protein Li 92n;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a glycoprotein, belonging to the pentraxin family of proteins, which has a characteristic pentameric organization. These family members have considerable sequence homology which is thought to be the result of gene duplication. The binding of the encoded protein to proteins in the pathological amyloid cross-beta fold suggests its possible role as a chaperone. This protein is also thought to control the degradation of chromatin. It has been demonstrated that this protein binds to apoptotic cells at an early stage, which raises the possibility that it is involved in dealing with apoptotic cells in vivo.

Pathway

Amyloids;