Anti-AP5Z1 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant protein corresponding to amino acids of human AP5Z1. The sequence is DDQWLNVQAFSMLRAWLLHSGPEGPGTLDTDDRSEQEGSTLSVISATSSAGRLLPPRERL REVAFEYCQRLIEQSNRRALRKGDSDLQKACLVEAVLVLDVLCRQDPSFLYRSLS

Conjugate

Application Notes

IHC: 1:200-1:500; WB: 1:250-1:500; IF: 1-4 μg/mL. & The optimal working dilution should be determined by the end user.

Alternative Names

AP5Z1; adaptor-related protein complex 5, zeta 1 subunit; zeta; SPG48; KIAA0415; AP-5 complex subunit zeta-1; zeta5; adapter-related protein complex 5 zeta subunit;

Entrez Gene ID

UniProt ID

Antigen Description

This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862).