Rabbit Anti-Human AP1AR Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthesized peptide derived from human AP1AR.

Conjugate

Application Notes

IHC 1:50-1:200
WB 1:500-1:2000

General Notes

This product (Catalog No. DPABH-05956) is a rabbit-derived polyclonal antibody raised against human AP1AR. It has been affinity purified by Protein A. Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.
DPABH-05956 is suitable for use in IHC 1 (50-1:200), WB 1 (500-1:2000) applications.
DPABH-05956 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Entrez Gene ID

UniProt ID