Anti-ANKRD1 monoclonal antibody (DCABH-10523) Made to order

Rabbit anti-Human ANKRD1 monoclonal antibody for WB, ELISA

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ANKRD1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ANKRD1; ankyrin repeat domain 1 (cardiac muscle); ankyrin repeat domain-containing protein 1; ALRP; C 193; CARP
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ANKRD1 (Ankyrin Repeat Domain 1) is a Protein Coding gene. Diseases associated with ANKRD1 include total anomalous pulmonary venous return and ankrd1-related dilated cardiomyopathy. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include transcription factor binding and histone deacetylase binding. An important paralog of this gene is ANKRD54. The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.
Pathway
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Hypertrophy Model, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; PPARA Activates Gene Expression, organism-specific biosystem; Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem.

Citations


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Custom Antibody Labeling


We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More

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References


Bunting, M; Tang, W; et al. Molecular cloning and characterization of a novel human diacylglycerol kinase zeta. JOURNAL OF BIOLOGICAL CHEMISTRY 271:10230-10236(1996).
Tian, YM; Yeoh, KK; et al. Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors. JOURNAL OF BIOLOGICAL CHEMISTRY 286:13041-13051(2011).

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