Anti-ANKK1 (internal region) polyclonal antibody

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to amino acids at internal region of human ANKK1. The sequence is C-SRQADPNLHEAEGKT

Conjugate

Application Notes

ELISA: 1:128000; WB: 0.1-0.3 μg/mL. & The optimal working dilution should be determined by the end user.

Alternative Names

ANKK1; ankyrin repeat and kinase domain containing 1; PKK2; ankyrin repeat and protein kinase domain-containing protein 1; sgK288; X-kinase; sugen kinase 288; protein kinase PKK2;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal transduction pathways. This gene is closely linked to DRD2 gene (GeneID:1813) on chr 11, and a well studied restriction fragment length polymorphism (RFLP) designated TaqIA, was originally associated with the DRD2 gene, however, later was determined to be located in exon 8 of ANKK1 gene (PMIDs: 18621654, 15146457), where it causes a nonconservative amino acid substitution. It is not clear if this gene plays any role in neuropsychiatric disorders previously associated with Taq1A RFLP.