Anti-ANKHD1 monoclonal antibody (DCABH-10522) Made to order

Rabbit anti-Human ANKHD1 monoclonal antibody for WB, ELISA

View other ANKHD1 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ANKHD1 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ANKHD1; ankyrin repeat and KH domain containing 1; ankyrin repeat and KH domain-containing protein 1; FLJ10042; FLJ11979; FLJ14127
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ANKHD1 (Ankyrin Repeat And KH Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is TANC1. This gene encodes a protein with multiple ankyrin repeat domains and a single KH-domain. The protein is thought to function as a scaffolding protein, and it may be involved in the regulation of caspases and thereby play an antiapoptotic role in cell survival. Alternative splicing results in multiple transcript variants, one of which generates a fusion transcript (MASK-BP3) with the downstream eIF4E-binding protein 3 (EIF4EBP3) gene, resulting in a protein comprised of the ANKHD1 sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.
Antigen Description
This gene encodes a protein with multiple ankyrin repeat domains and a single KH-domain. Co-transcription of this gene and the neighboring downstream gene (EIF4EBP3) generates a transcript (MASK-BP3) which encodes a fusion protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. Ankyrin repeat and KH domain-containing protein 1 is a protein that in humans is encoded by the ANKHD1 gene. This gene encodes a protein with multiple ankyrin repeat domains and a single KH domain. Co-transcription of this gene and the neighboring downstream gene (EIF4EBP3) generates a transcript (MASK-BP3) which encodes a fusion protein composed of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. The function about ANKHD1 antigen include RNA binding; protein binding.

Citations


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References


Poulin, F; Brueschke, A; et al. Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK. JOURNAL OF BIOLOGICAL CHEMISTRY 278:52290-52297(2003).
Traina, F; Favaro, PMB; et al. ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1762:828-834(2006).

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