Anti-ANAPC2 monoclonal antibody, clone 2B7

Antibody Isotype

IgG2a

Clone

2B7

Species Reactivity

Mouse; Rat; Human; Monkey

Immunogen

Full length Human recombinant Apc2 protein produced in HEK293 cell (NP_037498).

Conjugate

Application Notes

WB: 1/500 - 1/2000; IHC-P: 1/150; Flow Cyt: 1/100; ICC/IF: 1/100;

Alternative Names

ANAPC2; anaphase promoting complex subunit 2; anaphase-promoting complex subunit 2; APC2; KIAA1406; cyclosome subunit 2; RP11-350O14.5;

Entrez Gene ID

UniProt ID

Antigen Description

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of Lys-11-linked polyubiquitin chains and, to a lower extent, the formation of Lys-48- and Lys-63-linked polyubiquitin chains.

Pathway

APC/C complex, organism-specific biosystem; APC/C complex, conserved biosystem; APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; APC/C:Cdc2 mediated degradation of Cyclin B, organism-specific biosystem; APC/C:Cdc2 mediated degradation of Securin, organism-specific biosystem; APC/C:Cdc2 mediated degradation of mitotic proteins, organism-specific biosystem; APC/C:Cdh1 mediated degradation of Cdc2 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, organism-specific biosystem.