Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene.
Pathway
Signal Transduction; Signaling by Hippo.
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody. Learn More
Citations
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Sugihara-Mizuno, Y; Adachi, M; et al. Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. GENES TO CELLS 12:473-486(2007).
Li, ZQ; Wang, YQ; et al. The Amotl2 Gene Inhibits Wnt/beta-Catenin Signaling and Regulates Embryonic Development in Zebrafish. JOURNAL OF BIOLOGICAL CHEMISTRY 287:13005-13015(2012).
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