ALOX12B (NP_001130, 171 a.a. ~ 261 a.a) partial recombinant protein with GST tag. The sequence is NPNRPEWNGYIPGFPILINFKATKFLNLNLRYSFLKTASFFVRLGPMALAFKVRGLLDCK HSWKRLKDIRKIFPGKKSVVSEYVAEHWAED
This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma.
Pathway
Arachidonic acid metabolism; IL23-mediated signaling events; Metabolism of lipids and lipoproteins; Synthesis of 12-eicosatetraenoic acid derivatives
Citations
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