General Notes
This product (Catalog No. DPABH-28143) is a rabbit-derived polyclonal antibody raised against human ALDOC, targeting the amino acid region 34–281 of the protein. This antibody exhibits cross-reactivity with Human ALDOC from mouse and rat. It has been affinity purified by Protein A. Aldolase C, officially known as fructose-bisphosphate aldolase C, is a cytosolic enzyme encoded by the human ALDOC gene located on chromosome 17q11.2, belonging to the class I aldolase family. It primarily catalyzes the reversible aldol cleavage of fructose-1,6-bisphosphate (F1,6BP) into dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (G3P) as the fourth step in glycolysis, while also supporting gluconeogenesis and fructose metabolism by acting on fructose-1-phosphate. This brain-specific isoform, one of three vertebrate aldolases (alongside muscle-type ALDOA and liver-type ALDOB), exhibits tissue-restricted expression, with high levels in the hippocampus and Purkinje cells, underscoring its role in neuronal energy metabolism.
DPABH-28143 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-28143 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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